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PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome A Genome-Wide Meta-Analysis

Journal article
Authors M. Mola-Caminal
C. Carrera
C. Soriano-Tarraga
E. Giralt-Steinhauer
R. M. Daaz-Navarro
S. Tur
Carmen Jiménez
A. Medina-Dols
N. Cullell
N. P. Torres-Aguila
E. Muino
A. Rodriguez-Campello
A. Ois
E. Cuadrado-Godia
R. M. Vivanco-Hidalgo
M. Hernandez-Guillamon
M. Sol
P. Delgado
A. Bustamante
T. Garcia-Berrocoso
M. Mendioroz
M. Castellanos
J. Serena
J. Marti-Fabregas
T. Segura
G. Serrano-Heras
V. Obach
M. Rib
C. A. Molina
J. Alvarez-Sabin
E. Palomeras
M. Freijo
M. A. Font
J. Rosand
N. S. Rost
C. Gallego-Fabrega
J. M. Lee
L. Heitsch
L. Ibanez
C. Cruchaga
C. L. Phuah
R. Lemmens
V. Thijs
A. Lindgren
J. Maguire
K. Rannikmae
C. L. Sudlow
C. Jern
Tara M Stanne
Erik Lorentzen
L. Munoz-Narbona
A. Davalos
E. Lopez-Cancio
B. B. Worrall
D. Woo
S. J. Kittner
B. D. Mitchell
J. Montaner
J. Roquer
J. Krupinski
X. Estivill
R. Rabionet
C. Vives-Bauz
I. Fernandez-Cadenas
J. Jimenez-Conde
Published in Circulation research
Volume 124
Issue 1
Pages 114-120
ISSN 0009-7330
Publication year 2019
Published at Institute of Biomedicine
Core Facilities, Bioinformatics
Pages 114-120
Language en
Links dx.doi.org/10.1161/circresaha.118.3...
Keywords allele, genetic loci, genetic variant, genome-wide association study, ischemic stroke, genetics, scale
Subject categories Medical Genetics, Cardiovascular medicine, Hematology

Abstract

Rationale: Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. Objective: Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date. Methods and Results: A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, beta=0.40, P=1.70x10-9). Conclusions: Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci.

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