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Furry animal allergen component sensitization and clinical outcomes in adult asthma and rhinitis.

Journal article
Authors Bright I Nwaru
Shintaro Suzuki
Linda Ekerljung
Sigrid Sjölander
Roxana Mincheva
Erik P Rönmark
Madeleine Rådinger
Eva Rönmark
Magnus P. Borres
Bo Lundbäck
Jan Lötvall
Published in The journal of allergy and clinical immunology. In practice
Volume 7
Issue 4
Pages 1230-1238
ISSN 2213-2201
Publication year 2019
Published at Krefting Research Centre
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 1230-1238
Language en
Subject categories Clinical Medicine, Health Sciences


Sensitization to allergen components has been linked to asthma in children, but studies in adults are lacking.To study the relation of sensitization to furry animal allergen components to risk of asthma, rhinitis, and markers of asthma severity in adults.From the West Sweden Asthma Study, a random population-representative sample of adults aged 16-75 years, 2006 participants were clinically examined; 1872 were analyzed for serum IgE to a mix of aeroallergens. Those with IgE>0.35 kUA/L to cat, dog or horse were analyzed for specific cat (Fel d 1, Fel d 2, and Fel d 4), dog (Can f 1, Can f 2, Can f 3, and Can f 5), and horse (Equ c 1) allergen components. We defined mono-, double-, and poly-sensitization (>2 components) patterns and applied cluster analysis to derive distinct sensitization clusters.Sensitization to each allergen component, lipocalins, each sensitization pattern, and each sensitization cluster (non-sensitized, Fel d 1-driven sensitized, and multi-sensitized clusters) was associated with substantial increased risk of asthma, rhinitis, concomitant asthma/rhinitis, and ACT-controlled asthma. Fel d 1, Can f 1, 2, 3, poly-sensitization, and multi-sensitized cluster were further associated with increased FeNO and eosinophil levels, but with lower PD20 methacoline values. There was no association with asthma exacerbations, FEV1 predicted values, emergency visits or regular oral steroid use, and neutrophil levels.Sensitization to furry animal allergen components are important predictors of asthma, rhinitis and markers of asthma severity with increased blood eosinophils, FeNO, and airway hyper-reactivity.

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