To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

On oxytocin and social be… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

On oxytocin and social behavior

Doctoral thesis
Authors Daniel Hovey
Date of public defense 2018-11-09
ISBN 978-91-7833-145-1
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Language en
Links hdl.handle.net/2077/56891
Keywords oxytocin, social cognition, autism, antisocial behavior, zebrafish
Subject categories Pharmaceutical Sciences

Abstract

Complex social cognitive processes underlie social behavior. Oxytocin has long been recognized as crucial in social behavior in animals, but its role in regulating human social cognition and behavior is less clear, particularly with regard to endogenous oxytocin. The aims of this thesis were to investigate (i) how endogenous oxytocin affects face and emotion recognition in humans, (ii) how it may modulate social impairments in autism spectrum disorder and antisocial behavior, (iii) how exogenous (intranasal) oxytocin may influence the salience of human faces, and finally (iv) the role of endogenous oxytocin in zebrafish social behavior. We investigated endogenous oxytocin by studying genetic variation in oxytocin-related genes, and found that oxytocin influences social cognition in humans, specifically via modulation of face recognition (Paper I) and via modulation of emotion recognition in women (Paper II). In addition, we found tentative associations between variation in oxytocin-related genes and autistic-like traits in the general population (Paper III), and showed that variation in the oxytocin receptor gene is associated with antisocial behavior in men (Paper IV). We also showed that exogenous (intranasal) oxytocin acts to increase the salience of human faces (Paper V), a mechanism that may underlie its behavioral effects. Finally, we demonstrated that an oxytocin receptor antagonist decreases social preference in adult and larval zebrafish (Paper VI). In conclusion, this thesis confirms the importance of endogenous oxytocin for social cognition in humans, and demonstrates one mechanism by which exogenous oxytocin may act. Furthermore, we established an animal model for future research on the oxytocin system.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?