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ATP Hydrolysis in the RecA-DNA Filament Promotes Structural Changes at the Protein-DNA Interface

Journal article
Authors Anna Reymer
Sándor Babik
Masayuki Takahashi
Bengt Nordén
Tamás Beke-Somfai
Published in Biochemistry
Volume 54
Pages 4579-4582
ISSN 0006-2960
Publication year 2015
Published at Department of Chemistry and Molecular Biology
Pages 4579-4582
Language en
Links doi.org/10.1021/acs.biochem.5b00614
Subject categories Quantum chemistry, Biophysical chemistry, Biological physics

Abstract

To address the mechanistic roles of ATP hydrolysis in RecA-promoted strand exchange reaction in homologous recombination, quantum mechanical calculations are performed on key parts of the RecA-DNA complex. We find that ATP hydrolysis may induce changes at the protein-DNA interface, resulting in the rearrangement of the hydrogen bond network connecting the ATP and the DNA binding sites.

Page Manager: Webmaster|Last update: 9/11/2012
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