To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Airflow limitation classi… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Airflow limitation classified with the fixed ratio or the lower limit of normal and cause-specific mortality - A prospective study

Journal article
Authors Kjell Torén
M. Andersson
Anna-Carin Olin
P. D. Blanc
B. Jarvholm
Published in Respiratory Medicine
Volume 144
Pages 36-41
ISSN 0954-6111
Publication year 2018
Published at Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
Pages 36-41
Language en
Keywords Epidemiology, COPD, GOLD, Spirometry, Never smokers, Women, obstructive pulmonary-disease, swedish construction workers, lung-function, follow-up, general-population, society statement, increased risk, never-smokers, copd, cohort
Subject categories Public Health, Global Health, Social Medicine and Epidemiology


Background: There is controversy as to whether airflow limitation should be defined as forced expiratory volume in 1 s (FEV1)/vital capacity (VC) < 0.7 or as FEV1/VC < the lower limit of normal (LLN). The aim was to examine whether different definitions of airflow limitation differ in predicting mortality. Methods: Longitudinal prospective study of a national cohort of Swedish workers (199,408 men; 7988 women), aged 20-64 years with spirometry without bronchodilation at baseline followed from 1979 until death, or censorship at 2010. Airflow limitation (AL) by Global Obstructive Lung Disease criteria, AL(GOLD), was defined as FEV1/VC < 0.7; AL(LLN) as FEV1/VC < LLN. All all-cause, COPD and cardiovascular disease mortality was analyzed among men and women in relation to ALGOLD and ALLLN, adjusted for age and smoking. Results: Among men, all-cause mortality risks were similar by airflow limitation criteria: AL(GOLD) RR = 1.32, 95% CI 1.26-1.38; AL(LLN), RR = 1.37, 95% CI 1.31-1.44. The risk estimates were also similar by airflow limitation definition for cardiovascular mortality and for COPD mortality. Among women, all-cause mortality was also similar by airflow limitation criteria, but significantly higher as compared to men: AL(GOLD) RR = 2.10, 95% CI 1.66-2.66; AL(LLN), RR = 2.09, 95% CI 1.66-2.62. Also cardiovascular and COPD mortality by airflow limitation criteria was significantly higher among women as compared to men. Conclusions: Defined either as FEV1/VC < 0.7 or as FEV1/VC < LLN, airflow limitation predicted excess mortality risk of similar magnitude. Mortality in relation to airflow limitation was higher among women compared to men.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?