To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Separating and Segregatin… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Separating and Segregating the Human Mitochondrial Genome

Journal article
Authors Thomas J. Nicholls
Claes M Gustafsson
Published in Trends in Biochemical Sciences
Volume 43
Issue 11
Pages 869-881
ISSN 0968-0004
Publication year 2018
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 869-881
Language en
Links dx.doi.org/10.1016/j.tibs.2018.08.0...
Keywords DNA-polymerase gamma, optic atrophy, human mtdna, in-vitro, superresolution fluorescence, nucleoid organization, binding-properties, accessory subunit, topoisomerase-i, inner membrane
Subject categories Cell and Molecular Biology, Biochemistry and Molecular Biology

Abstract

Cells contain thousands of copies of the mitochondrial genome. These genomes are distributed within the tubular mitochondrial network, which is itself spread across the cytosol of the cell. Mitochondrial DNA (mtDNA) replication occurs throughout the cell cycle and ensures that cells maintain a sufficient number of mtDNA copies. At replication termination the genomes must be resolved and segregated within the mitochondrial network. Defects in mtDNA replication and segregation are a cause of human mitochondrial disease associated with failure of cellular energy production. This review focuses upon recent developments on how mitochondrial genomes are physically separated at the end of DNA replication, and how these genomes are subsequently segregated and distributed around the mitochondrial network.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?