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beta 7 integrins contribute to intestinal tumor growth in mice

Journal article
Authors S. Das
C. Donas
Paulina Akeus
Marianne Quiding-Järbrink
J. R. Mora
E. J. Villablanca
Published in PLoS ONE
Volume 13
Issue 9
ISSN 1932-6203
Publication year 2018
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Language en
Keywords colorectal-cancer, t-cells, colon carcinogenesis, tumorigenesis, inflammation, model, progression, statistics, activation, prevention
Subject categories Cancer and Oncology


The gut homing receptor integrin alpha 4 beta 7 is essential for the migration of pro-inflammatory T cells into the gut mucosa. Since intestinal neoplasia has been associated with chronic inflammation, we investigated whether interfering with gut-homing affects intestinal tumorigenesis. Using chemically induced and spontaneous intestinal tumor models we showed that lack of beta 7 integrin significantly impairs tumor growth without affecting tumor frequencies, with a mild translatable effect on overall survival. This correlates with human data showing lower MAdCAM-1 expression and disease-free survival in colorectal cancer patients. Thus, paradoxically in contrast to extra-intestinal tumors, blocking migration of immune cells into the gut might have a positive therapeutic effect on intestinal neoplasia.

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