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XLSY: Extra-Large NMR Spectroscopy.

Journal article
Authors Yulia Pustovalova
Maxim Mayzel
Vladislav Orekhov
Published in Angewandte Chemie (International ed. in English)
Volume 57
Issue 43
Pages 14043-14045
ISSN 1521-3773
Publication year 2018
Published at Swedish NMR Centre at Göteborg University
Department of Chemistry and Molecular Biology
Pages 14043-14045
Language en
Subject categories Biophysics, Biochemistry and Molecular Biology, Structural Biology


NMR studies of intrinsically disordered proteins and other complex biomolecular systems require spectra with the highest resolution and dimensionality. An efficient approach, extra-large NMR spectroscopy, is presented for experimental data collection, reconstruction, and handling of very large NMR spectra by a combination of the radial and non-uniform sampling, a new processing algorithm, and rigorous statistical validation. We demonstrate the first high-quality reconstruction of a full seven-dimensional HNCOCACONH and two five-dimensional HACACONH and HN(CA)CONH experiments for a representative intrinsically disordered protein α-synuclein. XLSY will significantly enhance the NMR toolbox in challenging biomolecular studies.

Page Manager: Webmaster|Last update: 9/11/2012

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