To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

How is cardiac troponin r… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

How is cardiac troponin released from injured myocardium?

Journal article
Authors J. Mair
B. Lindahl
Ola Hammarsten
C. Muller
E. Giannitsis
K. Huber
M. Mockel
M. Plebani
K. Thygesen
A. S. Jaffe
Acca Acute Cardiovasc Care Assoc
Published in European Heart Journal-Acute Cardiovascular Care
Volume 7
Issue 6
Pages 553-560
ISSN 2048-8726
Publication year 2018
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Pages 553-560
Language en
Keywords Cardiac troponin I, cardiac troponin T, myocardial injury, release, reversible, necrosis, apoptosis, irreversible cell-damage, membrane repair, ischemia, permeability, heart, rat, classification, regeneration, definition, predictors
Subject categories Cardiovascular medicine


Cardiac troponin I and cardiac troponin T are nowadays the criterion biomarkers for the laboratory diagnosis of acute myocardial infarction due to their very high sensitivities and specificities for myocardial injury. However, still many aspects of their degradation, tissue release and elimination from the human circulation are incompletely understood. Myocardial injury may be caused by a variety of different mechanisms, for example, myocardial ischaemia, inflammatory and immunological processes, trauma, drugs and toxins, and myocardial necrosis is preceded by a substantial reversible prelethal phase. Recent experimental data in a pig model of myocardial ischaemia demonstrated cardiac troponin release into the circulation from apoptotic cardiomyocytes as an alternative explanation for clinical situations with increased cardiac troponin without any other evidence for myocardial necrosis. However, the comparably lower sensitivities of all currently available imaging modalities, including cardiac magnetic resonance imaging for the detection of particularly non-focal myocardial necrosis in patients, has to be considered for cardiac troponin test result interpretation in clinical settings without any other evidence for myocardial necrosis apart from increased cardiac troponin concentrations as well.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?