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Human Adult Neurogenesis: Evidence and Remaining Questions

Journal article
Authors G. Kempermann
F. H. Gage
L. Aigner
H. J. Song
M. A. Curtis
S. Thuret
Hans-Georg Kuhn
S. Jessberger
P. W. Frankland
H. A. Cameron
E. Gould
R. Hen
D. N. Abrous
N. Toni
A. F. Schinder
X. Y. Zhao
P. J. Lucassen
J. Frisen
Published in Cell Stem Cell
Volume 23
Issue 1
Pages 25-30
ISSN 1934-5909
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 25-30
Language en
Keywords enhanced synaptic plasticity, hippocampal neurogenesis, human brain, dentate gyrus, granule cells, neurons, proliferation, doublecortin, period, rats, Cell Biology
Subject categories Medical cell biology


Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

Page Manager: Webmaster|Last update: 9/11/2012

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