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An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

Journal article
Authors J. T. Serviss
N. Andrews
Jimmy Van den Eynden
F. C. Richter
M. Houtman
M. Vesterlund
L. Schwarzmueller
P. Johnsson
Erik Larsson
D. Grander
K. P. Tamm
Published in Cell Death & Disease
Volume 9
ISSN 2041-4889
Publication year 2018
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Language en
Links dx.doi.org/10.1038/s41419-018-0777-...
Keywords long noncoding rnas, cell lung-cancer, ms-gf plus, human genome, transcriptional activation, hepatocellular-carcinoma, neuronal, differentiation, mir-34a, protein, gene, Cell Biology
Subject categories Cancer and Oncology

Abstract

The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this study, we find that a long noncoding RNA transcribed antisense to the miR34a host gene, is critical for miR34a expression and mediation of its cellular functions in multiple types of human cancer. We name this long noncoding RNA lncTAM34a, and characterize its ability to facilitate miR34a expression under different types of cellular stress in both TP53-deficient and wild-type settings.

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