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Human skin commensals augment Staphylococcus aureus pathogenesis.

Journal article
Authors Emma Boldock
Bas G J Surewaard
Daria Shamarina
Manli Na
Ying Fei
Abukar Ali
Alexander Williams
Eric J G Pollitt
Piotr Szkuta
Paul Morris
Tomasz K Prajsnar
Kathy D McCoy
Tao Jin
David H Dockrell
Jos A G van Strijp
Paul Kubes
Stephen A Renshaw
Simon J Foster
Published in Nature microbiology
Volume 3
Issue 8
Pages 881-90
ISSN 2058-5276
Publication year 2018
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 881-90
Language en
Links dx.doi.org/10.1038/s41564-018-0198-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Microbiology in the medical area, Immunology in the medical area, Infectious Medicine, Rheumatology and Autoimmunity

Abstract

All bacterial infections occur within a polymicrobial environment, from which a pathogen population emerges to establish disease within a host. Emphasis has been placed on prevention of pathogen dominance by competing microflora acting as probiotics1. Here we show that the virulence of the human pathogen Staphylococcus aureus is augmented by native, polymicrobial, commensal skin flora and individual species acting as 'proinfectious agents'. The outcome is pathogen proliferation, but not commensal. Pathogenesis augmentation can be mediated by particulate cell wall peptidoglycan, reducing the S. aureus infectious dose by over 1,000-fold. This phenomenon occurs using a range of S. aureus strains and infection models and is not mediated by established receptor-mediated pathways including Nod1, Nod2, Myd88 and the NLPR3 inflammasome. During mouse sepsis, augmentation depends on liver-resident macrophages (Kupffer cells) that capture and internalize both the pathogen and the proinfectious agent, leading to reduced production of reactive oxygen species, pathogen survival and subsequent multiple liver abscess formation. The augmented infection model more closely resembles the natural situation and establishes the role of resident environmental microflora in the initiation of disease by an invading pathogen. As the human microflora is ubiquitous2, its role in increasing susceptibility to infection by S. aureus highlights potential strategies for disease prevention.

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