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Cracking the Sugar Code by Mass Spectrometry

Journal article
Authors Ekaterina Mirgorodskaya
Niklas G Karlsson
Carina Sihlbom
Göran Larson
C. L. Nilsson
Journal Of Organic Chemistry V. P. Rr Sa
Published in Journal of the American Society for Mass Spectrometry
Volume 29
Issue 6
Pages 1065-1074
ISSN 1044-0305
Publication year 2018
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Core Facilities, Proteomics
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 1065-1074
Language en
Links doi.org/10.1007/s13361-018-1912-3
Keywords Glycan mass spectrometry, History of mass spectrometry, Structural mass spectrometry, Review, assisted laser-desorption, electron-capture dissociation, fast-atom-bombardment, post-source decay, permethylated, oligosaccharides, structural-characterization, glycomics experiment, spectral characterization, trichomonas-vaginalis, glycosylation sites, Biochemistry & Molecular Biology, Chemistry, Spectroscopy, ou dkh, 1989, journal of biological chemistry, v264, p3409, ahl b, 1991, analytical chemistry, v63, p1463, rupat k, 1991, international journal of mass spectrometry and ion processes, v111, p89
Subject categories Biochemistry and Molecular Biology

Abstract

The structural study of glycans and glycoconjugates is essential to assign their roles in homeostasis, health, and disease. Once dominated by nuclear magnetic resonance spectroscopy, mass spectrometric methods have become the preferred toolbox for the determination of glycan structures at high sensitivity. The patterns of such structures in different cellular states now allow us to interpret the sugar codes in health and disease, based on structure-function relationships. Dr. Catherine E. Costello was the 2017 recipient of the American Society for Mass Spectrometry's Distinguished Contribution Award. In this Perspective article, we describe her seminal work in a historical and geographical context and review the impact of her research accomplishments in the field.

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