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High doses of Antisecretory Factor stop diarrhea fast without recurrence for six weeks post treatment

Journal article
Authors S. Zaman
K. Aamir
Lars Åke Hanson
Stefan Lange
Published in International Journal of Infectious Diseases
Volume 71
Pages 48-52
ISSN 1201-9712
Publication year 2018
Published at Institute of Biomedicine
Institute of Biomedicine, Department of Microbiology and Immunology
Pages 48-52
Language en
Keywords Paediatric diarrheal disease, Antisecretory Factor, Developing country, Recovery time, Follow up, inflammatory-bowel-disease, childhood diarrhea, menieres-disease, trial, food, Infectious Diseases
Subject categories Pediatrics, Infectious Medicine


Background: Diarrheal illnesses in young children cause morbidity and preventable deaths in developing countries. We evaluated two high doses of Salovum (R) [Antisecretory Factor] to treat diarrhea in young children and followed up for recurrence 6 weeks post treatment. Methods: Forty children, 6-24 months old, admitted with acute diarrhea, to the Outpatient Department of Children's Hospital in Lahore, Pakistan were selected. The patients were randomly allocated to either Group A given 2 sachets, or to Group B, given 4 sachets. Each sachet contained 4 gram of Salovum (R) and was mixed with Oral Rehydration Salt solution. This mixture was administered perorally within the first 30 min of treatment. The trained nursing staff observed them for number of stools and consistency over every half hour for a total of 4 hours. Follow up for 6 weeks was done daily by telephone, or visits by the mothers. The results demonstrate that Salovum (R) provides a protective effect irrespective of the diarrhea causes. Results: Group B, given 4 sachets of Salovum (R) showed improved fecal consistency in 80% of the children compared to 50% in Group A within 30 minutes of treatment, p= 0.004. The number of diarrheal stools decreased over this time from seven to one/two over 4 hours in the two groups [p = 0.234]. None of the children showed a recurrence of diarrhea over the follow up period. Conclusion: Peroral high doses of Salovum (R) rapidly and safely counteract diarrhea in children followed by a diarrhea-free period of 6 weeks. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

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