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Technical challenges of working with extracellular vesicles

Journal article
Authors M. I. Ramirez
M. G. Amorim
C. Gadelha
I. Milic
J. A. Welsh
V. M. Freitas
Muhammad Nawaz
N. Akbar
Y. Couch
L. Makin
F. Cooke
A. L. Vettore
P. X. Batista
R. Freezor
J. A. Pezuk
L. Rosa-Fernandes
A. C. O. Carreira
A. Devitt
L. Jacobs
I. T. Silva
G. Coakley
D. N. Nunes
D. Carter
G. Palmisano
E. Dias-Neto
Published in Nanoscale
Volume 10
Issue 3
Pages 881-906
ISSN 2040-3364
Publication year 2018
Published at Institute of Medicine
Pages 881-906
Language en
Links https://doi.org/10.1039/C7NR08360B
Keywords Materials properties, Nanostructured materials, Extracellular, Molecular patterns, Nano-sized particles, Pathological conditions, Sugar content, Technical challenges, Nucleic acids
Subject categories Biomaterials Science, Bio Materials, Nano Technology

Abstract

Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nanosized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review. © 2018 The Royal Society of Chemistry.

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