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Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Journal article
Authors Björn O. Schröder
George M. H. Birchenough
Marcus Ståhlman
Liisa Arike
Malin E V Johansson
Gunnar C. Hansson
Fredrik Bäckhed
Published in Cell Host & Microbe
Volume 23
Issue 1
Pages 27-40
ISSN 1931-3128
Publication year 2018
Published at Wallenberg Laboratory
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 27-40
Language en
Links dx.doi.org/10.1016/j.chom.2017.11.0...
Keywords inulin-type fructans, gut microbiota, bacterial symbiont, metabolic, syndrome, innate immunity, induced obesity, mucin, mice, susceptibility, oligofructose, Microbiology, Parasitology, Virology, ates of america, v107, p14691, ates of america, v105, p15064, ates of america, v110, p9066
Subject categories Biochemistry and Molecular Biology

Abstract

Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis.

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