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Cyclin C influences the timing of mitosis in fission yeast.

Journal article
Authors Gabor Banyai
Zsolt Szilagyi
Vera Baraznenok
Olga Khorosjutina
Claes M Gustafsson
Published in Molecular biology of the cell
Volume 28
Issue 13
Pages 1738-1744
ISSN 1939-4586
Publication year 2017
Published at Institute of Biomedicine
Pages 1738-1744
Language en
Links dx.doi.org/10.1091/mbc.E16-11-0787
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Biochemistry and Molecular Biology

Abstract

The multiprotein Mediator complex is required for the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator contains the Cdk8 regulatory subcomplex, which directs periodic transcription and influences cell cycle progression in fission yeast. Here we investigate the role of CycC, the cognate cyclin partner of Cdk8, in cell cycle control. Previous reports suggested that CycC interacts with other cellular Cdks, but a fusion of CycC to Cdk8 reported here did not cause any obvious cell cycle phenotypes. We find that Cdk8 and CycC interactions are stabilized within the Mediator complex and the activity of Cdk8-CycC is regulated by other Mediator components. Analysis of a mutant yeast strain reveals that CycC, together with Cdk8, primarily affects M-phase progression but mutations that release Cdk8 from CycC control also affect timing of entry into S phase.

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