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Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women

Journal article
Authors A. Vincent
O. I. Savolainen
P. Sen
N. G. Carlsson
A. Almgren
Helen Lindqvist
M. V. Lind
I. Undeland
A. S. Sandberg
A. B. Ross
Published in Molecular Nutrition & Food Research
Volume 61
Issue 3
ISSN 1613-4125
Publication year 2017
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Language en
Links doi.org/10.1002/mnfr.201600400
Keywords Arginine, Central energy metabolism, Chicken, Herring, Pork, clupea-harengus, mass-spectrometry, glyoxylate cycle, stone disease, amino-acids, fish, diet, consumption, fractions, cohort, Food Science & Technology
Subject categories Food Engineering, Food Science

Abstract

Scope: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome? Method and results: A randomised crossover trial with 15 healthy obese men and women (age 24-70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics. The herring diet decreased plasma citrate, fumarate, isocitrate, glycolate, oxalate, agmatine and methyhistidine and increased asparagine, ornithine, glutamine and the hexosamine glucosamine. Modelling found that the tricarboxylic acid cycle, glyoxylate, and arginine metabolism were affected by the intervention. The effect on arginine metabolism was supported by an increase in blood nitric oxide in males on the herring diet. Conclusion: The results suggest that eating herring instead of chicken and lean pork leads to important metabolic effects, particularly on energy and amino acid metabolism. Our findings support the hypothesis that there are metabolic effects of herring intake unrelated to the long chain n-3 polyunsaturated fatty acid content.

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