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Changes in HbA(1c) and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture

Journal article
Authors Elisabet Stener-Victorin
M. Maliqueo
M. Soligo
V. Protto
L. Manni
Elisabeth Jerlhag
Milana Kokosar
Antonina Sazonova
Carl Johan Behre
Marcus Lind
Claes Ohlsson
K. Hojlund
Anna Benrick
Published in Obesity Science & Practice
Volume 2
Issue 4
Pages 426-435
ISSN 2055-2238
Publication year 2016
Published at Institute of Neuroscience and Physiology, Department of Physiology
Centre for Bone and Arthritis Research
Institute of Neuroscience and Physiology, Department of Pharmacology
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 426-435
Language en
Links dx.doi.org/10.1002/osp4.78
https://gup.ub.gu.se/file/206883
Keywords Acupuncture, adipose tissue, hyperandrogenism, insulin resistance, sympathetic nervous system, RANDOMIZED CONTROLLED-TRIAL, LOW-FREQUENCY ELECTROACUPUNCTURE, SYMPATHETIC-NERVE ACTIVITY, INSULIN SENSITIVITY, PHYSICAL-EXERCISE, METABOLIC SYNDROME, DIABETES-MELLITUS, GENE-EXPRESSION, RAT MODEL, ACUPUNCTURE
Subject categories Endocrinology and Diabetes, Physiology

Abstract

Aim Insulin sensitivity is similar to 40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS. Seventeen women with PCOS, aged 18 to 38years, with a body mass index (BMI) >= 25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole-body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA(1c), circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF). No significant change in glucose homeostasis was observed, but HbA(1c) decreased by 9.5% (p=0.004), circulating testosterone decreased by 22% (p=0.0007) and dihydrotestosterone decreased by 12% (p=0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21% (p=0.027) and 20% (p=0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18% (p=0.049), and androstenedione decreased by 13% (p=0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p=0.04). These changes occurred without changes in anthropometrics. Five weeks of electroacupuncture treatment improves HbA(1c) and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).

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