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Flavonoids from Erythrina schliebenii

Journal article
Authors Stephen S. Nyandoro
Joan J. E. Munissi
M. Kombo
C. A. Mgina
F. F. Pan
Amra Gruhonjic
Paul A. Fitzpatrick
Y. Lu
B. Wang
K. Rissanen
Mate Erdelyi
Published in Journal of Natural Products
Volume 80
Issue 2
Pages 377-383
ISSN 0163-3864
Publication year 2017
Published at Swedish NMR Centre at Göteborg University
Sahlgrenska Cancer Center
Department of Chemistry and Molecular Biology
Pages 377-383
Language en
Keywords stem bark, caffra thunb, pterocarpan, isoflavanones, isoflavones, orientalis, addisoniae, sacleuxii, tanzania, Plant Sciences, Pharmacology & Pharmacy
Subject categories Biochemistry and Molecular Biology


Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2-4), and nineteen known natural products (5-23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32-64 mu g mL(-1) and 36.9-101.8 mu M, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0-290.6 mu M (pure compounds) and 38.3 to >100 mu g mL(-1) (crude extracts). RAMSON D, 1973, PHYTOCHEMISTRY, V12, P2211

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