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Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs

Journal article
Authors Josefine Persson
Yuan Zhang
Torunn Olafsdottir
Karolina Thörn
T. M. Cairns
F. Wegmann
Q. J. Sattentau
R. J. Eisenberg
G. H. Cohen
Ali M Harandi
Published in Frontiers in Immunology
Volume 7
ISSN 1664-3224
Publication year 2016
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Language en
Links https://doi.org/10.3389/fimmu.2016....
Keywords genital herpes, nasal immunization, neutralizing antibody, competitive surface plasmon resonance, simplex-virus type-2, glycoprotein-d, intranasal immunization, protective immunity, cpg-oligodeoxynucleotides, mucosal adjuvant, recombinant gd2, vaccine, hsv-2, infection, lean cs, 1994, journal of infectious diseases, v170, p1100
Subject categories Rheumatology and Autoimmunity

Abstract

Genital herpes is one of the most prevalent sexually transmitted infections in both the developing and developed world. Following infection, individuals experience life-long latency associated with sporadic ulcerative outbreaks. Despite many efforts, no vaccine has yet been licensed for human use. Herein, we demonstrated that nasal immunization with an adjuvanted HSV-2 gD envelope protein mounts significant protection to primary infection as well as the establishment of latency and recurrent genital herpes in guinea pigs. Nasal immunization was shown to elicit specific T cell proliferative and IFN responses as well as systemic and vaginal gD-specific IgG antibody (Ab) responses. Furthermore, systemic IgG Abs displayed potent HSV-2 neutralizing properties and high avidity. By employing a competitive surface plasmon resonance (SPR) analysis combined with a battery of known gD-specific neutralizing monoclonal Abs (MAbs), we showed that nasal immunization generated IgG Abs directed to two major discontinuous neutralizing epitopes of gD. These results highlight the potential of nasal immunization with an adjuvanted HSV-2 envelope protein for induction of protective immunity to primary and recurrent genital herpes.

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