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Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice

Journal article
Authors M. A. La Merrill
S. Sethi
L. Benard
E. Moshier
Börje Haraldsson
C. Buettner
Published in Environmental Health Perspectives
Volume 124
Issue 11
Pages 1722-1727
ISSN 0091-6765
Publication year 2016
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1722-1727
Language en
Keywords persistent organic pollutants, cardiovascular-disease, gene-expression, blood-pressure, organochlorine pesticides, beta-cells, fetal, 2,3,7,8-tetrachlorodibenzo-p-dioxin, association, growth, Environmental Sciences & Ecology, Public, Environmental & Occupational, Health, Toxicology
Subject categories Environmental medicine, Cardiac and Cardiovascular Systems, Toxicology


BACKGROUND: Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its use in the 1970s. However, the use of DDT to control vector-borne diseases continues in developing countries. Prenatal DDT exposure is associated with elevated blood pressure in humans. OBJECTIVE: We hypothesized that perinatal DDT exposure causes hypertension in adult mice. METHODS: DDT was administered to C57BL/6J dams from gestational day 11.5 to postnatal day 5. Blood pressure (BP) and myocardial wall thickness were measured in male and female adult offspring. Adult mice were treated with an angiotensin converting enzyme (ACE) inhibitor, captopril, to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhibition. We further assessed the influence of DDT exposure on the expression of mRNAs that regulate BP through renal ion transport. RESULTS: Adult mice perinatally exposed to DDT exhibited chronically increased systolic BP, increased myocardial wall thickness, and elevated expression of mRNAs of several renal ion transporters. Captopril completely reversed hypertension in mice perinatally exposed to DDT. CONCLUSIONS: These data demonstrate that perinatal exposure to DDT causes hypertension and cardiac hypertrophy in adult offspring. A key mechanism underpinning this hypertension is an overactivated renin angiotensin system because ACE inhibition reverses the hypertension induced by perinatal DDT exposure.

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