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Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.

Journal article
Authors Pia Larsson
I Alwis
B Niego
M Sashindranath
Per Fogelstrand
M C L Wu
Lars Glise
Mia Magnusson
M Daglas
Niklas Bergh
S P Jackson
R L Medcalf
Sverker Jern
Published in Journal of thrombosis and haemostasis : JTH
Volume 14
Issue 12
Pages 2496–2508
ISSN 1538-7836
Publication year 2016
Published at Wallenberg Laboratory
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 2496–2508
Language en
Links dx.doi.org/10.1111/jth.13527
Subject categories Cardiovascular medicine

Abstract

The endogenous fibrinolytic system has rarely been considered as a target to prevent thrombotic disease. Tissue plasminogen activator (t-PA) is potently increased by histone deacetylase (HDAC) inhibitors in endothelial cells in vitro, but whether this translates into increased vascular t-PA production and an enhanced fibrinolytic capacity in vivo is unknown.

Page Manager: Webmaster|Last update: 9/11/2012
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