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Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.

Journal article
Authors Pia Larsson
I Alwis
B Niego
M Sashindranath
Per Fogelstrand
M C L Wu
Lars Glise
Mia Magnusson
M Daglas
Niklas Bergh
S P Jackson
R L Medcalf
Sverker Jern
Published in Journal of thrombosis and haemostasis : JTH
Volume 14
Issue 12
Pages 2496–2508
ISSN 1538-7836
Publication year 2016
Published at Wallenberg Laboratory
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 2496–2508
Language en
Subject categories Cardiovascular medicine


The endogenous fibrinolytic system has rarely been considered as a target to prevent thrombotic disease. Tissue plasminogen activator (t-PA) is potently increased by histone deacetylase (HDAC) inhibitors in endothelial cells in vitro, but whether this translates into increased vascular t-PA production and an enhanced fibrinolytic capacity in vivo is unknown.

Page Manager: Webmaster|Last update: 9/11/2012

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