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Validation of a flow cytometry-based detection of γ-H2AX, to measure DNA damage for clinical applications.

Journal article
Authors Pegah Johansson
Anders Fasth
Torben Ek
Ola Hammarsten
Published in Cytometry. Part B, Clinical cytometry
Volume 92
Pages 534–540
ISSN 1552-4957
Publication year 2017
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Institute of Clinical Sciences, Department of Pediatrics
Pages 534–540
Language en
Links dx.doi.org/10.1002/cyto.b.21374
Subject categories Pediatrics, Medical cell biology

Abstract

The nucleosomal histone protein H2AX is specifically phosphorylated (γ-H2AX) adjacent to DNA double-strand breaks (DSBs) and is used for quantifying DSBs. Many chemotherapies and ionizing radiation (IR) used in cancer treatment result in DSBs. Therefore, γ-H2AX has a significant potential as a biomarker in evaluating patient sensitivity and responsiveness to IR and chemotherapy.

Page Manager: Webmaster|Last update: 9/11/2012
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