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Neutrophils from patients with SAPHO syndrome show no signs of aberrant NADPH oxidase-dependent production of intracellular reactive oxygen species.

Journal article
Authors Per Wekell
Halla Björnsdottir
Lena Björkman
Martina Sundqvist
Karin Christenson
Veronica Osla
Stefan Berg
Anders Fasth
Amanda Welin
Johan Bylund
Anna Karlsson
Published in Rheumatology (Oxford, England)
Volume 55
Issue 8
Pages 1489-98
ISSN 1462-0332
Publication year 2016
Published at Institute of Odontology
Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Clinical Sciences, Department of Pediatrics
Pages 1489-98
Language en
Subject categories Pediatrics, Immunology in the medical area


We aimed to investigate if aberrant intracellular production of NADPH oxidase-derived reactive oxygen species (ROS) in neutrophils is a disease mechanism in the autoinflammatory disease SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis and osteitis, as has previously been suggested based on a family with SAPHO syndrome-like disease.

Page Manager: Webmaster|Last update: 9/11/2012

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