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The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy

Journal article
Authors Mattias K Andersson
Göran Stenman
Published in Oral Oncology
Volume 57
Pages 63-69
ISSN 1368-8375
Publication year 2016
Published at Sahlgrenska Cancer Center
Institute of Biomedicine, Department of Pathology
Pages 63-69
Language en
Keywords Chromosome translocations, Gene fusions, Mutation, Biomarker, Salivary gland cancer, Targeted, adenoid cystic carcinoma, nut midline carcinoma, analog secretory, carcinoma, acute lymphoblastic-leukemia, copy number alterations, ex, pleomorphic adenoma, factor-i receptor, duct carcinoma, mucoepidermoid, carcinomas, kinase inhibitor, Oncology, Dentistry
Subject categories Clinical Medicine


Recent studies of the genomic landscape of salivary gland tumors have provided important insights into the molecular pathogenesis of these tumors. The most consistent alterations identified include a translocation-generated gene fusion network involving transcription factors, transcriptional coactivators, tyrosine kinase receptors, and other kinases. In addition, next-generation sequencing studies of a few subtypes of salivary neoplasms have revealed hotspot mutations in individual genes and mutations clustering to specific pathways frequently altered in cancer. Although limited, these studies have opened up new avenues for improved classification and targeted therapies of salivary gland cancers. In this review, we summarize the latest developments in this field, focusing on tumor types for which clinically important molecular data are available.

Page Manager: Webmaster|Last update: 9/11/2012

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