To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

The relationship between … - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

The relationship between eGFR and hospitalization for heart failure in 54,486 individuals with type 2 diabetes

Journal article
Authors Mauro Tancredi
Annika Rosengren
Marita Olsson
Soffia Gudbjörnsdottir
A. M. Svensson
Börje Haraldsson
Marcus Lind
Volume 32
Issue 7
Pages 730-735
ISSN 1520-7560
Publication year 2016
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 730-735
Language en
Keywords heart failure; glomerular filtration rate; type 2 diabetes mellitus; chronic kidney disease; hospitalization; prognosis
Subject categories Clinical Medicine


BACKGROUND: To study the association between renal function and hospitalization for heart failure (HF) in individuals with type 2 diabetes. METHODS: Renal function was determined according to 3 formulas used to estimate glomerular filtration rate (eGFR): Cockcroft-Gault, Modified Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology (CKD-EPI). Proportional hazards regression models adjusted for age, sex, HbA1c, blood pressure, smoking, and cardiovascular comorbidities were constructed for each eGFR formula to estimate risk of HF hospitalization. RESULTS: In 54,486 patients, using Cockcroft-Gault, 41% were categorized as having normal renal function (eGFR > 90 ml/min), compared to 22.9% using MDRD and 21.6% using CKD-EPI. In the cohort, there were 21%-24% (depending on eGFR formula) with eGFR < 60 ml/min of whom 1.0%-1.5% had eGFR < 30 ml/min. Over a median follow-up of 7.0 years, a total of 5936 (10.9%) developed heart failure, with an excess risk in all eGFR categories below 60 ml/min/1.73 m2 (reference: eGFR > 90 ml/min/1.73 m2). Hazard ratios (HRs) ranged from 1.25 to 1.35 for eGFR 45-60 ml/min/1.73 m2,1.62 to 1.66 for eGFR 30-45 ml/min/1.73 m2, and 2.18 to 2.52 for eGFR <30 ml/min/1.73 m2 in the three eGFR formulas. CONCLUSIONS: Patients with type 2 diabetes, with eGFR 45 to 60 ml/min/1.73 m2 , have approximately 25%-35% increased risk of hospitalization for HF, increasing with lower eGFR, to 2-2.5 times in those with eGFR <30 ml/min/1.73 m2.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?