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Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery

Review article
Authors Muhammad Nawaz
Farah Fatima
I. Nazarenko
Karin Ekström
I. Murtaza
M. Anees
A. Sultan
L. Neder
G. Camussi
Hadi Valadi
J. A. Squire
T. Kislinger
Published in Expert Review of Proteomics
Volume 13
Issue 4
Pages 395-409
ISSN 1478-9450
Publication year 2016
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Clinical Sciences, Department of Biomaterials
Pages 395-409
Language en
Links dx.doi.org/10.1586/14789450.2016.11...
Keywords glycoproteins, ovarian cancer, microRNAs, matrix metalloproteinase, Extracellular vesicles, cell-derived exosomes, membrane-vesicles, dendritic cells, pancreatic-cancer, carcinoma cells, fas ligand, intercellular, communication, diagnostic biomarkers, serous adenocarcinoma, potential, biomarker
Subject categories Medical Biotechnology, Clinical Medicine

Abstract

In recent years there has been tremendous interest in both the basic biology and applications of extracellular vesicles (EVs) in translational cancer research. This includes a better understanding of their biogenesis and mechanisms of selective cargo packaging, their precise roles in horizontal communication, and their application as non-invasive biomarkers. The rapid advances in next-generation omics technologies are the driving forces for these discoveries. In this review, the authors focus on recent results of EV research in ovarian cancer. A deeper understanding of ovarian cancer-derived EVs, the types of cargo molecules and their biological roles in cancer growth, metastases and drug resistance, could have significant impact on the discovery of novel biomarkers and innovative therapeutics. Insights into the role of EVs in immune regulation could lead to novel approaches built on EV-based immunotherapy.

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