To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Monitoring polydispersity… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Monitoring polydispersity by NMR diffusometry with tailored norm regularisation and moving-frame processing

Journal article
Authors M. Urbanczyk
Diana Bernin
A. Czuron
Krzysztof Kazimierczuk
Published in Analyst
Volume 141
Issue 5
Pages 1745-1752
ISSN 0003-2654
Publication year 2016
Published at Swedish NMR Centre at Göteborg University
Pages 1745-1752
Language en
Links dx.doi.org/10.1039/c5an02304a
Keywords nuclear-magnetic-resonance, field gradient nmr, diffusion measurements, curve resolution, spectroscopy, algorithm, dosy, inversion, mixtures, polymers, Chemistry
Subject categories Chemical Sciences

Abstract

Nuclear magnetic resonance (NMR) is currently one of the main analytical techniques applied in numerous branches of chemistry. Furthermore, NMR has been proven to be useful to follow in situ reactions occurring on a time scale of hours and days. For complicated mixtures, NMR experiments providing diffusion coefficients are particularly advantageous. However, the inverse Laplace transform (ILT) that is used to extract the distribution of diffusion coefficients from an NMR signal is known to be unstable and vulnerable to noise. Numerous regularisation techniques to circumvent this problem have been proposed. In our recent study, we proposed a method based on sparsity-enforcing l(1)-norm minimisation. This approach, which is referred to as ITAMeD, has been successful but limited to samples with a 'discrete' distribution of diffusion coefficients. In this paper, we propose a generalisation of ITAMeD using a tailored l(p)-norm (1 <= p <= 2) to process, in particular, signals arising from 'polydisperse' samples. The performance of our method was tested on simulations and experimental datasets of polyethylene oxides with varying polydispersity indices. Finally, we applied our new method to monitor diffusion coefficient and polydispersity changes of heparin undergoing enzymatic degradation in real time.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?