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Cytotoxic Effects of Valproic Acid on Neuroendocrine Tumour Cells.

Journal article
Authors Yvonne Arvidsson
Viktor Johanson
Roswitha Pfragner
Bo Wängberg
Ola Nilsson
Published in Neuroendocrinology
Volume 103
Issue 5
Pages 578-591
ISSN 1423-0194
Publication year 2016
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Biomedicine, Department of Pathology
Sahlgrenska Cancer Center
Pages 578-591
Language en
Subject categories Cancer and Oncology, Surgery


Histone deacetylases (HDACs) modulate lysine acetylation on histones and are frequently deregulated in cancer. HDAC inhibitors with potent anti-tumour effects have been developed and are now being tested in clinical trials. The aim of this study was to investigate the effects of valproic acid (VPA), an inhibitor of class-I and class-IIa HDACs, on neuroendocrine tumour (NET) cell growth.

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