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Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.

Journal article
Authors Akilan Krishnamurthy
Vijay Joshua
Aase Haj Hensvold
Tao Jin
Meng Sun
Nancy Vivar
A Jimmy Ytterberg
Marianne Engström
Cátia Fernandes-Cerqueira
Khaled Amara
Malin Magnusson
Gustaf Wigerblad
Jungo Kato
Juan Miguel Jiménez-Andrade
Kerry Tyson
Stephen Rapecki
Karin Lundberg
Sergiu-Bogdan Catrina
Per-Johan Jakobsson
Camilla Svensson
Vivianne Malmström
Lars Klareskog
Heidi Wähämaa
Anca I Catrina
Published in Annals of the rheumatic diseases
Volume 75
Issue 4
Pages 721-729
ISSN 1468-2060
Publication year 2016
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 721-729
Language en
Links dx.doi.org/10.1136/annrheumdis-2015...
Subject categories Rheumatology and Autoimmunity

Abstract

Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of ACPAs in osteoclast (OC) activation and to identify key cellular mediators in this process.

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