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Molecular signatures of vaccine adjuvants

Journal article
Authors Torunn Olafsdottir
Madelene Lindqvist
Ali M Harandi
Published in Vaccine
Volume 33
Issue 40
Pages 5302-5307
ISSN 0264-410X
Publication year 2015
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 5302-5307
Language en
Keywords Vaccine adjuvants, Systems biology, Omics, Mode of action of adjuvants, in-water emulsion, responses, systems, immune, metabolomics, mouse, mf59, inflammasome, formulation, mechanism, Immunology, Research & Experimental Medicine
Subject categories Microbiology in the medical area


Mass vaccination has saved millions of human lives and improved the quality of life in both developing and developed countries. The emergence of new pathogens and inadequate protection conferred by some of the existing vaccines such as vaccines for tuberculosis, influenza and pertussis especially in certain age groups have resulted in a move from empirically developed vaccines toward more pathogen tailored and rationally engineered vaccines. A deeper understanding of the interaction of innate and adaptive immunity at molecular level enables the development of vaccines that selectively target certain type of immune responses without excessive reactogenicity. Adjuvants constitute an imperative element of modern vaccines. Although a variety of candidate adjuvants have been evaluated in the past few decades, only a limited number of vaccine adjuvants are currently available for human use. A better understanding of the mode of action of adjuvants is pivotal to harness the potential of existing and new adjuvants in shaping a desired immune response. Recent advancement in systems biology powered by the emerging cutting edge omics technology has led to the identification of molecular signatures rapidly induced after vaccination in the blood that correlate and predict a later protective immune response or vaccine safety. This can pave ways to prospectively determine the potency and safety of vaccines and adjuvants. This review is intended to highlight the importance of big data analysis in advancing our understanding of the mechanisms of actions of adjuvants to inform rational development of future human vaccines. (C) 2015 The Authors. Published by Elsevier Ltd.

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