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Potential neuroprotective strategies for perinatal infection and inflammation

Journal article
Authors S. M. Ranchhod
K. C. Gunn
T. M. Fowke
J. O. Davidson
C. A. Lear
J. Bai
L. Bennet
Carina Mallard
A. J. Gunn
J. M. Dean
Published in International Journal of Developmental Neuroscience
Volume 45
Pages 44-54
ISSN 0736-5748
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 44-54
Language en
Links dx.doi.org/10.1016/j.ijdevneu.2015....
Keywords Perinatal, Infection, Inflammation, Cytokines, Brain injury, White matter, Lipopolysaccharide, white-matter injury, low-birth-weight, extremely preterm infants, neonatal-rat brain, oligodendrocyte lineage progression, hypoxic-ischemic encephalopathy, necrosis-factor-alpha, periventricular, leukomalacia, systemic inflammation, cerebral-palsy, Developmental Biology, Neurosciences & Neurology
Subject categories Neuroscience, Neurology

Abstract

Preterm born infants have high rates of brain injury, leading to motor and neurocognitive problems in later life. Infection and resulting inflammation of the fetus and newborn are highly associated with these disabilities. However, there are no established neuroprotective therapies. Microglial activation and expression of many cytokines play a key role in normal brain function and development, as well as being deleterious. Thus, treatment must achieve a delicate balance between possible beneficial and harmful effects. In this review, we discuss potential neuroprotective strategies targeting systemic infection or the resulting systemic and central inflammatory responses. We highlight the central importance of timing of treatment and the critical lack of studies of delayed treatment of infection/inflammation. (C) 2015 Elsevier Ltd. All rights reserved.

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