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The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease

Journal article
Authors S. Makitalo
Åsa Mellgren
Ellen Borgh
L. Kilander
Tobias Skillbäck
Henrik Zetterberg
Magnus Gisslén
Published in Aids Research and Therapy
Volume 12
Pages Article Number: 23
ISSN 1742-6405
Publication year 2015
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Biomedicine, Department of Infectious Medicine
Pages Article Number: 23
Language en
Links dx.doi.org/10.1186/s12981-015-0063-...
Keywords Alzheimer's disease, HIV, CSF biomarkers, NEUROFILAMENT PROTEIN NFL, CENTRAL-NERVOUS-SYSTEM, ANTIRETROVIRAL, THERAPY, FRONTOTEMPORAL DEMENTIA, UNINFECTED INDIVIDUALS, LIFE, EXPECTANCY, RISK-FACTORS, TAU-PROTEIN, CSF, COHORT, Infectious Diseases, ATES OF AMERICA, V83, P4913, ARTHUR JC, 1993, NEUROLOGY, V43, P2245
Subject categories Infectious Medicine

Abstract

It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of A beta 42 and normal levels of CSF neurofilament light protein and sAPP alpha and sAPP beta, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.

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