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IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice.

Journal article
Authors Abukar Ali
Manli Na
Mattias Svensson
Malin Magnusson
Amanda Welin
Jan-Christoph Schwarze
Majd Mohammad
Elisabet Josefsson
Rille Pullerits
Tao Jin
Published in PloS one
Volume 10
Issue 7
Pages e0131645
ISSN 1932-6203
Publication year 2015
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages e0131645
Language en
Links dx.doi.org/10.1371/journal.pone.013...
Subject categories Immunobiology

Abstract

Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections.

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