To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

The effect of exercise on… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

The effect of exercise on angiogenic factors in the healthy mouse heart: A short report

Journal article
Authors Christina Karazisi
Aron Onerup
Pia Larsson
Lena M S Carlsson
Mats Börjesson
Smita DuttaRoy
Published in Experimental and Clinical Cardiology
Volume 20
Issue 1
Pages 2332-2341
ISSN 1205-6626
Publisher Pulsus Group Inc.
Publication year 2014
Published at Wallenberg Laboratory
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 2332-2341
Language en
Keywords Endothelial progenitor cells, Exercise, Heart, angiogenic factor, hypoxia inducible factor 1alpha, messenger RNA, stromal cell derived factor 1, vasculotropin, angiogenesis, animal experiment, animal tissue, article, cardiovascular effect, cardiovascular risk, controlled study, coronary artery blood flow, endothelial progenitor cell, female, fluorescence activated cell sorting, heart muscle, hindlimb, hypoxia, mouse, muscle growth, NMRI mouse, nonhuman, protein expression, reverse transcription polymerase chain reaction, sedentary lifestyle, sitting, treadmill exercise
Subject categories Health Sciences


Background: Exercise increases blood levels of crucial angiogenic factors and endothelial progenitor cells (EPCs). Hypoxia inducible factor-1 (HIF-1a) and vascular endothelial growth factor (VEGF) are also increased in skeletal muscle in response to exercise. In the healthy heart, voluntary exercise is not expected to cause local hypoxia. We studied how voluntary exercise affects cardiac expression of HIF-1a, VEGF and stromal derived factor-1 (SDF-1), as well as EPC levels in heart and skeletal muscle. Method: Thirty-two NMRI mice were randomized to exercise in running wheels (EX) or regular activity (SED). HIF-1a, VEGF and SDF-1 mRNA levels were analyzed by reverse transcription polymerase chain reaction (RT-PCR) and EPC levels in heart and hind limb were quantified by FACS after 7 and 14 days. Results: There was no significant difference in cardiac expression of HIF-1a, VEGF or SDF-1 between EX and SED. Cardiac EPC levels were not affected by exercise, while skeletal EPC level was more than doubled. Conclusion: Voluntary exercise does not seem to induce cardiac hypoxia or stimulate the angiogenic system. In the healthy normoxic heart, there is a limited need of supporting blood supply, which might explain these findings.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?