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Down-regulation of survivin alleviates experimental arthritis.

Journal article
Authors Karin Andersson
Mattias Svensson
Malin Erlandsson
Ing-Marie Jonsson
Maria Bokarewa
Published in Journal of leukocyte biology
Volume 97
Issue 1
Pages 135-45
ISSN 1938-3673
Publication year 2015
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 135-45
Language en
Links dx.doi.org/10.1189/jlb.3A0714-317R
Subject categories Basic Medicine

Abstract

Survivin is a proto-oncogene that regulates cell division and apoptosis. It is a molecular marker of cancer. Recently, survivin has emerged as a feature of RA, associated with severe joint damage and poor treatment response. The present study examined if inhibition of survivin affects experimental arthritis, which was induced in mBSA-immunized mice by an injection of mBSA in the knee joint or developed spontaneously in collagen type II-immunized mice. The inhibition of survivin transcription by a lentivirus shRNA construct alleviated joint inflammation and reduced bone damage. The inhibition of survivin reduced the levels of metalloproteinases, β-catenin, and vimentin, limiting the invasive capacity of synovia, while no inhibition of osteoclastogenesis could be found. The inhibition of survivin led to a p53-independent reduction of T cell proliferation and favored the transcription and activity of Blimp-1, which limited IL-2 production and facilitated formation of regulatory Foxp3(+)CD4(+) and effector CD8(+) T cells. The study shows that the inhibition of survivin is sufficient to reduce joint inflammation and bone damage in preclinical models of arthritis. Antiarthritic effects of survivin inhibition are related to p53-independent control of lymphocyte proliferation.

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