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ARFGAP1 Is Dynamically Associated with Lipid Droplets in Hepatocytes

Journal article
Authors J. Gannon
Julia Fernandez-Rodriguez
H. Alamri
S. B. Feng
F. Kalantari
S. Negi
A. H. Y. Wong
A. Mazur
Lennart Asp
A. Fazel
A. Salman
A. Lazaris
P. Metrakos
J. J. M. Bergeron
T. Nilsson
Published in Plos One
Volume 9
Issue 11
ISSN 1932-6203
Publication year 2014
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Language en
Links dx.doi.org/10.1371/journal.pone.011...
Keywords ADP-RIBOSYLATION FACTOR, GTPASE-ACTIVATING PROTEIN, GOLGI-COMPLEX, COPI, VESICLES, ENDOPLASMIC-RETICULUM, BINDING PROTEINS, COATED VESICLES, PHOSPHOLIPASE-D, BETA-COP, ARF, Multidisciplinary Sciences, ATES OF AMERICA, V110, P13244
Subject categories Clinical Medicine

Abstract

The ARF GTPase Activating Protein 1 (ARFGAP1) associates mainly with the cytosolic side of Golgi cisternal membranes where it participates in the formation of both COPI and clathrin-coated vesicles. In this study, we show that ARFGAP1 associates transiently with lipid droplets upon addition of oleate in cultured cells. Also, that addition of cyclic AMP shifts ARFGAP1 from lipid droplets to the Golgi apparatus and that overexpression and knockdown of ARFGAP1 affect lipid droplet formation. Examination of human liver tissue reveals that ARFGAP1 is found associated with lipid droplets at steady state in some but not all hepatocytes.

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