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Acute escitalopram but not contextual conditioning exerts a stronger "anxiogenic" effect in rats with high baseline "anxiety" in the acoustic startle paradigm.

Journal article
Authors Robert Pettersson
Jakob Näslund
Staffan Nilsson
Elias Eriksson
S Melker Hagsäter
Published in Psychopharmacology
Volume 232
Issue 8
Pages 1461-1469
ISSN 0033-3158
Publication year 2015
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 1461-1469
Language en
Links dx.doi.org/10.1007/s00213-014-3783-...
Subject categories Other pharmacy

Abstract

Acute administration of selective serotonin reuptake inhibitors (SSRIs) may enhance anxiety in humans, those with anxiety disorders being more susceptible than others. Fear-conditioned or unconditioned acoustic startle and freezing are common measures of fear and/or "anxiety" in rodents that may be used to study this effect of SSRIs preclinically.

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