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Vitamin B12 as a potential compliance marker for fish intake

Journal article
Authors Nathalie Scheers
Helen Lindqvist
Anna Maria Langkilde
Ingrid Undeland
Ann-Sofie Sandberg
Published in European Journal of Nutrition
Volume 53
Issue 6
Pages 1327-1333
ISSN 1436-6207
Publication year 2014
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 1327-1333
Language en
Keywords Biomarker, Marker, Compliance, Fish, Intake, Vitamin B12
Subject categories Nutrition and Dietetics


Objectives: The aim of the present study was to investigate whether the following four markers; Vitamin B12, selenium, vitamin D, and parvalbumin may be used as compliance markers for fish intake. Methods: Blood samples from a randomized cross-over herring intervention study (n=32) were analyzed by HPLC and immunochemistry. The criteria were that plasma or serum concentrations of candidate compliance markers after the herring diet should increase significantly compared to starting concentrations. In addition, the reference meat diet should not yield an increase in plasma concentration of the candidate marker. Results: Vitamin B12 and selenium met the set criteria for indicating a correlation between the marker and fish intake with significant increases in serum concentrations at 8.9% (p=0.008) and 4.6% (p=0.02) respectively after a 6-week herring intervention (5 meals a week). Parvalbumin and 25-hydroxy vitamin D3 levels did not increase significantly during the herring interventions. Conclusions: Vitamin B12 may be suitable as a compliance marker for fish intake. Although selenium also met the criteria, the change in selenium serum concentrations was small compared to the change in vitamin B12 levels.

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