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Serum proteome changes following human immunodeficiency virus infection.

Journal article
Authors David Haarburger
Jörgen Bergström
Tahir S Pillay
Published in Clinical laboratory
Volume 59
Issue 5-6
Pages 639-46
ISSN 1433-6510
Publication year 2013
Published at Core Facilities, Proteomics
Pages 639-46
Language en
Links https://www.clin-lab-publications.c...
Keywords Adult, Biological Markers, blood, Blood Proteins, metabolism, Databases, Factual, Electrophoresis, Gel, Two-Dimensional, HIV Infections, blood, Humans, Male, Mass Spectrometry, Proteome, metabolism
Subject categories Chemistry, Clinical Medicine

Abstract

Quantification of viral RNA levels and CD4 cell count determinations are the most widely used laboratory assays employed in monitoring HIV patients. However, these tests are expensive, complex to perform, and require advanced laboratory infrastructure and highly skilled laboratory technicians. For these reasons, alternative ways to monitor the progression of HIV have been sought. The aim of this study was to compare the serum proteome of asymptomatic HIV-positive subjects to HIV-negative controls in order to identify novel protein changes that are induced in the human serum proteome following HIV infection. It is hoped that monitoring changes in these protein could be used as a cheaper biomarker for the progression of HIV infection.

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