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Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP.

Journal article
Authors Margareta Jernås
Yu Hou
Frida Strömberg Celind
Linlin Shao
Intawat Nookaew
Qian Wang
Xiuli Ju
Karin Mellgren
Hans Wadenvik
Ming Hou
Bob Olsson
Published in Blood
Volume 122
Issue 10
Pages 1789-92
ISSN 1528-0020
Publication year 2013
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 1789-92
Language en
Links dx.doi.org/10.1182/blood-2013-05-50...
Subject categories Pediatrics

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves, but in some it becomes chronic. To investigate whether these 2 phases of the disease are molecularly similar or separate entities we performed DNA microarray analysis (GEO accession number: GSE46922) of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the gene expression profiles between the 2 phases of the disease. Furthermore, the gene expression levels of several cytokines differed between the 2 phases of the disease. This was also reflected in plasma with increased levels of interleukin (IL)-16 and TNF-related weak inducer of apoptosis and lower levels of IL-4 in newly diagnosed compared with chronic ITP. Thus, our data indicate that chronic ITP in childhood is a separate disease entity, dissimilar in many aspects to the newly diagnosed phase.

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