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Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function.

Journal article
Authors Malin Erlandsson
Mattias Svensson
Ing-Marie Jonsson
Li Bian
Noona Ambartsumian
Sofia E M Andersson
Zhiqi Peng
Jukka Vääräniemi
Claes Ohlsson
Karin Andersson
Maria Bokarewa
Published in Biochimica et biophysica acta
Volume 1833
Issue 12
Pages 2653-2663
ISSN 0006-3002
Publication year 2013
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Centre for Bone and Arthritis Research
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 2653-2663
Language en
Keywords S100A4; Osteopetrosis; Bone; Osteoclasts; Cathepsin K; Adhesion molecules
Subject categories Endocrinology, Rheumatology and Autoimmunity


S100A4 is a Ca-binding protein that regulates cell growth, survival, and motility. The abundant expression of S100A4 in rheumatiod arthritis contributes to the invasive growth of joint tissue and to bone damage. In the present study, we analysed the role of S100A4 in bone homeostasis.

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