To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Age and diagnostic perfor… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Age and diagnostic performance of Alzheimer disease CSF biomarkers.

Journal article
Authors Niklas Mattsson
E Rosén
O Hansson
N Andreasen
L Parnetti
Michael Jonsson
S-K Herukka
W M van der Flier
M A Blankenstein
M Ewers
K Rich
E Kaiser
M M Verbeek
M Olde Rikkert
M Tsolaki
E Mulugeta
D Aarsland
P J Visser
J Schröder
J Marcusson
M de Leon
H Hampel
P Scheltens
Anders Wallin
M Eriksdotter-Jönhagen
L Minthon
B Winblad
Kaj Blennow
Henrik Zetterberg
Published in Neurology
Volume 78
Issue 7
Pages 468-76
ISSN 1526-632X
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 468-76
Language en
Keywords Adult, Aged, Aged, 80 and over, Aging, physiology, Alzheimer Disease, cerebrospinal fluid, diagnosis, Biological Markers, cerebrospinal fluid, Cohort Studies, Cross-Sectional Studies, Endpoint Determination, Female, Humans, Likelihood Functions, Longitudinal Studies, Male, Middle Aged, Mild Cognitive Impairment, cerebrospinal fluid, diagnosis, Models, Neurological, Predictive Value of Tests, ROC Curve, Reproducibility of Results, tau Proteins, cerebrospinal fluid
Subject categories Neurology


Core CSF changes in Alzheimer disease (AD) are decreased amyloid β(1-42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. These biomarkers identify AD already at the predementia stage, but their diagnostic performance might be affected by age-dependent increase of AD-type brain pathology in cognitively unaffected elderly.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?