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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

Journal article
Authors Margareta Jernås
Intawat Nookaew
Hans Wadenvik
Bob Olsson
Published in Blood
Volume 121
Issue 11
Pages 2095-2098
ISSN 1528-0020
Publication year 2013
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 2095-2098
Language en
Links dx.doi.org/10.1182/blood-2012-12-47...
https://gup.ub.gu.se/file/110605
Keywords Case-Control Studies, Cluster Analysis, Gene Expression Profiling, Humans, Microarray Analysis, MicroRNAs
Subject categories Hematology

Abstract

MicroRNA are small non-coding RNA molecules that regulate gene expression. To investigate the role of microRNA in ITP, we performed genome-wide expression analyses of mRNA and microRNA in T-cells from ITP patients and controls. We identified 1,915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with the immune system, e.g. T-cell activation and regulation of immunoglobulin production. CXCL13 and IL-21 were two microRNA target genes significantly increased in ITP. We could demonstrate increased plasma levels of CXCL13 and others have reported increased plasma levels of IL-21 in ITP. Thus, regulated microRNA were significantly associated with both gene and protein expression of molecules in immunological pathways. We suggest that microRNA may be important regulatory molecules involved in the loss of tolerance in ITP.

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