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Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas.

Journal article
Authors Nimrod B Kiss
Per Kogner
John Inge Johnsen
Tommy Martinsson
Catharina Larsson
Janos Geli
Published in BMC medical genetics
Volume 13
Pages 83
ISSN 1471-2350
Publication year 2012
Published at
Pages 83
Language en
Keywords Neuroblastoma, Pyrosequencing, CIMP, BLU, CASP8, DCR2, CDH1, RASSF1A, RASSF2
Subject categories Basic Medicine

Abstract

In this study we aimed to quantify tumor suppressor gene (TSG) promoter methylation densities levels in primary neuroblastoma tumors and cell lines. A subset of these TSGs is associated with a CpG island methylator phenotype (CIMP) in other tumor types.

Page Manager: Webmaster|Last update: 9/11/2012
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