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Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata

Journal article
Authors Milkyas Endale
John Patrick Alao
H. M. Akala
N. K. Rono
F. L. Eyase
S. Derese
A. Ndakala
M. Mbugua
D. S. Walsh
Per Sunnerhagen
Mate Erdelyi
Abiy Yenesew
Published in Planta Medica
Volume 78
Issue 1
Pages 31-35
ISSN 0032-0943
Publication year 2012
Published at Swedish NMR Centre at Göteborg University
Department of Chemistry and Molecular Biology
Pages 31-35
Language en
Keywords malaria, Pentas longiflora, Pentas lanceolata
Subject categories Organic Chemistry, Pharmacognosy, Pharmaceutical chemistry


The dichloromethane/methanol (1 : 1) extracts of the roots of Pentas longiflora and Pentas lanceolata showed low micromolar (IC50 = 0.9-3 µg/mL) in vitro antiplasmodial activity against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum. Chromatographic separation of the extract of Pentas longiflora led to the isolation of the pyranonaphthoquinones pentalongin (1) and psychorubrin (2) with IC50 values below 1 µg/mL and the naphthalene derivative mollugin (3), which showed marginal activity. Similar treatment of Pentas lanceolata led to the isolation of eight anthraquinones (4-11, IC50 = 5-31 µg/mL) of which one is new (5,6-dihydroxydamnacanthol, 11), while three - nordamnacanthal (7), lucidin-ω-methyl ether (9), and damnacanthol (10) - are reported here for the first time from the genus Pentas. The compounds were identified by NMR and mass spectroscopic techniques.

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