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A multilocus technique for risk evaluation of patients with neuroblastoma.

Journal article
Authors Inge M Ambros
Bettina Brunner
Gerhard Aigner
Clare Bedwell
Klaus Beiske
Jean Bénard
Nick Bown
Valerie Combaret
Jerome Couturier
Raffaella Defferrari
Nicole Gross
Marta Jeison
John Lunec
Barbara Marques
Tommy Martinsson
Katia Mazzocco
Rosa Noguera
Gudrun Schleiermacher
Frank Speleman
Ray Stallings
Gian Paolo Tonini
Deborah A Tweddle
Alexander Valent
Ales Vicha
Nadine Van Roy
Eva Villamon
Andrea Ziegler
Sandra Preuner
Mario Drobics
Ruth Ladenstein
Gabriele Amann
Robert J L Schuit
Ulrike Pötschger
Peter F Ambros
Published in Clinical cancer research : an official journal of the American Association for Cancer Research
Volume 17
Issue 4
Pages 792-804
ISSN 1078-0432
Publication year 2011
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Pages 792-804
Language en
Keywords Computer Graphics, Gene Amplification, Genetic Loci, Genetic Markers, Humans, Limit of Detection, Molecular Diagnostic Techniques, methods, Mutation, Neuroblastoma, genetics, pathology, Nuclear Proteins, genetics, Oncogene Proteins, genetics, Risk Assessment
Subject categories Medical Genetics


Precise and comprehensive analysis of neuroblastoma genetics is essential for accurate risk evaluation and only pangenomic/multilocus approaches fulfill the present-day requirements. We present the establishment and validation of the PCR-based multiplex ligation-dependent probe amplification (MLPA) technique for neuroblastoma.

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