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Interaction of Single Viruslike Particles with Vesicles Containing Glycosphingolipids

Journal article
Authors Marta Bally
Anders Gunnarsson
L. Svensson
Göran Larson
Vladimir P. Zhdanov
Fredrik Höök
Published in Physical Review Letters
Volume 107
Issue 18
ISSN 0031-9007
Publication year 2011
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Language en
Keywords mismatch discrimination, influenza-viruses, infection pathway, norwalk, virus, tracking, bilayers, noroviruses, binding, cells, entry
Subject categories Physical Sciences, Biophysical chemistry, Nano Technology, Virology, Clinical Laboratory Medicine


Glycosphingolipids are involved in the first steps of virus-cell interaction, where they mediate specific recognition of the host cell membrane. We have employed total-internal-reflection fluorescence microscopy to explore the interaction kinetics between individual unlabeled noroviruslike particles, which are attached to a glycosphingolipid-containing lipid bilayer, and fluorescent vesicles containing different types and concentrations of glycosphingolipids. Under association equilibrium, the vesicle-binding rate is found to be kinetically limited, yielding information on the corresponding activation energy. The dissociation kinetics are logarithmic over a wide range of time. The latter is explained by the vesicle-size-related distribution of the dissociation activation energy. The biological, pharmaceutical, and diagnostic relevance of the study is briefly discussed.

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