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Meta-analysis of neurobla… - University of Gothenburg, Sweden Till startsida
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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification.

Journal article
Authors Sara De Brouwer
Katleen De Preter
Candy Kumps
Piotr Zabrocki
Michaël Porcu
Ellen M Westerhout
Arjan Lakeman
Jo Vandesompele
Jasmien Hoebeeck
Tom Van Maerken
Anne De Paepe
Geneviève Laureys
Johannes H Schulte
Alexander Schramm
Caroline Van Den Broecke
Joëlle Vermeulen
Nadine Van Roy
Klaus Beiske
Marleen Renard
Rosa Noguera
Olivier Delattre
Isabelle Janoueix-Lerosey
Per Kogner
Tommy Martinsson
Akira Nakagawara
Miki Ohira
Huib Caron
Angelika Eggert
Jan Cools
Rogier Versteeg
Frank Speleman
Published in Clinical cancer research : an official journal of the American Association for Cancer Research
Volume 16
Issue 17
Pages 4353-62
ISSN 1078-0432
Publication year 2010
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Pages 4353-62
Language en
Keywords neuroblastom, alk
Subject categories Medical Genetics, Molecular medicine


Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and clinical parameters, and studied the prognostic significance of ALK copy number and expression.

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